STRINGSTRING
SCO0998 SCO0998 SCO0996 SCO0996 SCO0997 SCO0997 SCO0497 SCO0497 SCO1787 SCO1787 SCO7216 SCO7216 SCO2273 SCO2273 SCO7218 SCO7218 SCO7398 SCO7398 SCO0496 SCO0496 SCO1786 SCO1786
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO09982SCG2.11, ftrE, Fe uptake system permease, len: 272 aa; similar to previously sequenced and annotated as TR:Q9X470 (EMBL:AF099015) Streptomyces coelicolor Fe uptake system permease FtrE, 271 aa; fasta scores:opt: 1424 z-score: 1545.2 E(): 0; 89.5% identity in 257 aa overlap and similar to TR:CAB94640 (EMBL:AL359215) Streptomyces coelicolor putative iron transport protein, ATP-binding component SC2H12.16, 258 aa; fasta scores: opt: 834 z-score: 672.9 E(): 7.8e-32; 55.4% identity in 251 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter and matches to Prosite entr [...] (272 aa)    
Predicted Functional Partners:
SCO0996
2SCG2.09, possible lipoprotein, len: 347 aa; similar to TR:Q9K467 (EMBL:AL359215) Streptomyces coelicolor putative iron transport lipoprotein SC2H12.17, 345 aa; fasta scores: opt: 473 z-score: 540.7 E(): 1.4e-22; 39.2% identity in 339 aa overlap. Contains Pfam match to entry PF01497 Peripla_BP_2, Periplasmic binding protein, correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains possible N-terminal region signal peptide sequence.
 
 0.999
SCO0997
2SCG2.10, ftrD, Fe uptake system integral membrane protein, len: 371 aa; previously sequenced and annotated as TR:Q9X471 (EMBL:AF099015) Streptomyces coelicolor Fe uptake system integral membrane protein FtrD, 374 aa and similar to TR:CAB94639 (EMBL:AL359215) Streptomyces coelicolor putative FecCD-family membrane transport protein SC2H12.15, 368 aa; fasta scores: opt: 942 z-score: 839.0 E(): 0; 45.8% identity in 360 aa overlap. Contains Pfam match to entry PF01032 FecCD_family, FecCD transport family. Also contains possible hydrophobic membrane spanning regions.
 
 0.999
SCO0497
SCF34.16c, probable iron-siderophore permease transmembrane protein, len: 358 aa; similar to SW:FEPD_ECOLI (EMBL:X57471), FepD, Escherichia coli ferric enterobactin transport protein (334 aa), fasta scores; opt: 796 z-score: 833.5 E(): 0, 43.9% identity in 330 aa overlap and to many other iron-siderophore permeases. Similar to others from S.coelicolor e.g. SCI51.27c (EMBL:AL109848) S.coelicolor probable iron-siderophore uptake system transmembrane component (348 aa) (46.8% identity in 344 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Contains Pfam match to entr [...]
 
 
 0.927
SCO1787
SCI51.27c, probable iron-siderophore uptake system transmembrane component, len: 348 aa; similar to many transmembrane components from binding-protein-dependent iron uptake systems using a range of siderophores e.g. SW:FEPD_ECOLI (EMBL:X57471), fepD, Escherichia coli ferric enterobactin transport protein (334 aa), fasta scores; opt: 910 z-score: 991.5 E(): 0, 46.0% identity in 326 aa overlap. Similar to neighbouring SCI51.26c, probable iron-siderophore uptake system transmembrane component (375 aa) (37.9% identity in 348 aa overlap). Contains hydrophobic, possible membrane-spanning reg [...]
 
 
 0.927
SCO7216
SC2H12.15, possible FecCD-family membrane transport protein, len: 368 aa. Highly similar to many including: Yersinia pestis SW:HMUU_YERPE(EMBL:U60647) hemin transport system permease protein HmuU (334 aa), fasta scores opt: 674 z-score: 713.5 E(): 2.9e-32 40.4% identity in 342 aa overlap and Streptomyces coelicolor TR:Q9RKQ5(EMBL:AL133220) FecCD-family membrane transport protein, SCC75A.19 (363 aa), fasta scores opt: 777 z-score: 820.7 E():0 42.6% identity in 371 aa overlap. Contains possible membrane spanning hydrophobic domains, a possible N-terminal signal sequence and a Pfam match [...]
 
 
 0.926
SCO2273
SCC75A.19, FecCD-family membrane transport protein, len: 363 aa. Highly similar to proteins involved in iron acquisition including: Yersinia pestis SW:HMUU_YERPE(EMBL:U60647) hemin transport system permease protein HmuU (334 aa), fasta scores: opt: 855 z-score: 924.4 E():0 45.9% identity in 290 aa overlap and Corynebacterium diphtheriae TR:AAD37494(EMBL:AF109162) BC-type transporter permease (350 aa), fasta scores opt: 1006 z-score: 1085.8 E():0 47.2% identity in 339 aa overlap. Contains a Pfam match to entry PF01032 FecCD_family, FecCD transport family and multiple possible membrane s [...]
 
 
 0.925
SCO7218
SC2H12.17, possible iron transport lipoprotein, len: 345 aa. Similar to Streptomyces coelicolor TR:Q9RK12(EMBL:AL109974) putative iron-siderophore binding lipoprotein, SCF34.13C (350 aa), fasta scores opt: 221 z-score: 254.1 E(): 1.1e-06 28.7% identity in 352 aa overlap. Contains a possible N-terminal signal sequence and an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains a Pfam match to entry PF01497 Peripla_BP_2, Periplasmic binding protein.
 
 
 0.909
SCO7398
SC10G8.26c, possible membrane transport protein, len: 694 aa. Highly similar to many members of the FecCD family of binding protein-dependent transport proteins e.g. Escherichia coli SW:FHUB_ECOLI(EMBL:X04319) ferrichrome transport protein FhuB precursor (660 aa), fasta scores opt: 510 z-score:0.0 E(): 0.0 33.93% identity in 672 aa overlap. Contains 2xPfam match to entry PF01032 FecCD_family, FecCD transport family and multiple possible membrane spanning hydrophobic domains; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
 
 
 0.908
SCO0496
SCF34.15c, probable iron-siderophore permease transmembrane protein, len: 368 aa; similar to SW:FEPG_ECOLI (EMBL:X57471), FepG, Escherichia coli ferric enterobactin transport protein (330 aa), fasta scores; opt: 741 z-score: 794.3 E(): 0, 38.7% identity in 326 aa overlap and to many other iron-siderophore permeases. Similar to others from S. coelicolor e.g. SCI51.26c (EMBL:AL109848) S. coelicolor probable iron-siderophore uptake system transmembrane component (375 aa) (45.9% identity in 333 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Contains Pfam match to en [...]
 
  
 0.850
SCO1786
SCI51.26c, probable iron-siderophore uptake system transmembrane component, len: 375 aa; similar to many transmembrane components from binding-protein-dependent iron uptake systems using a range of siderophores e.g. SW:FEPG_ECOLI (EMBL:X57471), fepG, Escherichia coli ferric enterobactin transport protein (330 aa), fasta scores; opt: 946 z-score: 1034.3 E(): 0, 50.0% identity in 310 aa overlap. Similar to neighbouring SCI51.27c, probable iron-siderophore uptake system transmembrane component (348 aa) (37.9% identity in 348 aa overlap). Contains hydrophobic, possible membrane-spanning re [...]
 
  
 0.850
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.